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Lipid elongation in prostate cancer promotes survival through the unfolded protein response

Presentation Description

Institution: University of Adelaide - South Australia, Australia

The enzyme Elongation of Very Long Chain Fatty Acid 5 (ELOVL5)  has recently been identified as the main regulator of lipid elongation in prostate cancer and is required for  optimal prostate cancer cell growth and survival. The lipids elongated by ELOVL5  are predominantly incorporated into phosolipids for cell membranes, including organelle membranes such as the endoplasmic reticulum (ER). Changes to the ER membrane can induce lipid bilayer stress , which activates a cell survival mechansim known as the unfolded protein response (UPR). This study aims to determine whether ELOVL5 lipid elongation promotes prostates cancer cell survival through UPR activation.


Deanna Miller - University of Adelaide, SAHMRI Zeyad D Nassar - University of Adelaide, SAHMRI Julia S Scott - University of Adelaide, SAHMRI Chui Yan Mah - University of Adelaide, SAHMRI Lisa M Butler - University of Adelaide, SAHMRI Margaret M Centenera - University of Adelaide, SAHMRI