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Targeting peroxisomal fatty acid oxidation in advanced prostate cancer

Presentation Description

Institution: University of Adelaide - Adelaide, Australia

Fatty acid oxidation (FAO) is the dominant bioenergetic pathway in prostate cancer (PCa), and is critical for cancer cell viability and redox homeostasis. While most studies have focused on mitochondrial FAO, little is known about the potential roles of peroxisomal FAO in prostate cancer, nor its relevance in disease progression or treatment resistance. Here, we aimed to evaluate the efficacy of targeting peroxisomal FAO via the clinical inhibitor thioridazine (TDZ) on prostate cancer oncogenesis.

Authors

Chui Yan Mah - University of Adelaide Takuto Nijiima - University of Adelaide Zeyad Nassar - University of Adelaide Lisa Butler - University of Adelaide